Genetic variants in ADAM33 are associated with airway inflammation and lung function in COPD

Genetic variants in ADAM33 are associated with airway inflammation and lung function in COPD

BACKGROUND Genetic factors play a role in the development and severity of chronic obstructive pulmonary disease (COPD). The pathogenesis of COPD is a multifactorial process including an inflammatory cell profile. Recent studies revealed that single nucleotide polymorphisms (SNPs) within ADAM33 increased the susceptibility to COPD through changing the airway inflammatory process and lung functio...

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Adam33 polymorphisms are associated with COPD and lung function in long-term tobacco smokers

BACKGROUND Variation in ADAM33 has been shown to be important in the development of asthma and altered lung function. This relationship however, has not been investigated in the population susceptible to COPD; long term tobacco smokers. We evaluated the association between polymorphisms in ADAM33 gene with COPD and lung function in long term tobacco smokers. METHODS Caucasian subjects, at lea...

Airway Inflammation in COPD*

Inflammation of the airways has been regarded as a cardinal pathophysiologic feature of asthma for some 20 years. This concept has been based on evidence from a variety of sources: the histologic changes in the airway wall, hyperresponsiveness of the asthmatic airways to a wide range of natural and pharmacologic agents, the presence of activated inflammatory and immune cells and their mediators...

Eosinophilic airway inflammation in COPD

Chronic obstructive pulmonary disease is a common condition and a major cause of mortality. COPD is characterized by irreversible airflow obstruction. The physiological abnormalities observed in COPD are due to a combination of emphysema and obliteration of the small airways in association with airway inflammation. The predominant cells involved in this inflammatory response are CD8+ lymphocyte...